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COVID-19 is rearranging society. Fear, and worry about the virus are directly impacting the mental health of Americans. Our presentation examines the intersection of COVID-19 fear, worry, and perceived threat with social vulnerabilities and mental health consequences, namely depressive and anxiety symptomatology as well as suicidality. Using an online platform, a nationally representative sample (n = 10, 368) of U.S. adults was surveyed during the latter part of March 2020. The sample was post-strata weighted to ensure adequate representation of the U.S. population based on population estimates for gender, race/ethnicity, income, age, and geography. Our results are telling. Fear and worry are not distributed equally across the country; rather they are concentrated in places where the largest number of confirmed COVID-19 cases is found. Additionally, data illuminate significant differences in the subjective perception of fear and worry across groups with varying social vulnerabilities. Women, Hispanics, Asians, families with children under 18, and foreign-born respondents have higher levels of subjective fear and worry compared to their counterparts. Finally, even after controlling for social vulnerability, subjective assessments of distress are positive, and significantly related to depressive and anxiety symptomatology as well as suicidality. Prior research from China and Europe confirms what we are now beginning to document in the United States. Our preliminary work provides practitioners with a glimpse of what is ahead, which individuals and communities are vulnerable, and what types of strategic interventions might help to address the impending tsunami of mental health consequences for Americans in the months and years ahead.