The skin is innervated by three classes of afferent c-fibres that code for itch, pain and ‘pleasure’, and although research has described the functional properties of each class, in health and disease, they have largely been studied separately, leaving questions unanswered - and unasked - regarding any overlap and/or integration of these ‘parallel pathways’. For example, itch and pain interact in an antagonistic manner, the pleasure of scratching an itch is ‘relieved’ by pain. However, the ‘new kid on the block’, the CLTM, has almost exclusively been left of out of any interpretation of itch and/or pain mechanisms, let alone their functional role and significance to skin sensory processing.