Particle Manipulation through Actuated Microbubble Streaming

In recent years, there has been an increasing demand for non-contact methods to manipulate single particles, cells, and organisms in various fields, including biology, chemistry, engineering, and physics. This need arises from the wide range of applications that require precise manipulation of these entities, such as detection, focusing, mixing, counting, lysis, and analysis of single cells. To meet this demand, advanced lab-on-a-chip devices have been developed and successfully utilized to perform various functions. Additionally, advancements in micro- and nano-engineering have facilitated the rapid development of diverse technologies aimed at manipulating particles through improved biocompatible approaches. The integration of biocompatible microbubble streaming and Poiseuille flow has become a prominent feature of lab-on-a-chip devices in recent years, enabling various microfluidic applications.

At our research institute, we have implemented several techniques and demonstrated the practical integration of microbubble streaming into various applications. We have developed automated systems that utilize actuated microbubble streaming to manipulate microparticles within a microchannel. These systems exhibit high efficiency and are particularly suitable for applications in lab-on-a-chip technology, specifically in single-cell analysis, isolation, and removal. Furthermore, we employ various control and measurement techniques to observe, track, detect, and control microparticles, microbubbles, and flow fields in real time.



  • N.N.


Person in charge:

  • Amirabas Bakhtiari, MSc.



  • German Research Foundation (DFG)



  • Bakhtiari A, Kähler CJ (2022) Automated monitoring and positioning of single microparticle via ultrasound-driven microbubble streaming. Microfluidics and Nanofluidics 26:59
  • Bakhtiari A, Kähler CJ (2023) Automated microparticle positioning using a pair of ultrasound-actuated microbubbles for microfluidic applications. Microfluidics and Nanofluidics 27:1-9
  • Bakhtiari A, Kähler CJ (2023) Flow characterization of a combined Poiseuille flow and streaming of ultrasound-actuated microbubble using μPTV. 15th International Symposium on Particle Image Velocimetry – ISPIV 2023, June 19–21, San Diego, California, USA