Particle manipulation and separation in micro-flows via Bulk Acoustic Waves

The manipulation and separation of micro/nano-particles is becoming essential in several fields, e.g. separating healthy cells from cancer cells in a blood stream is a classic example in biomedicine of great importance nowadays and for which there are currently no effective techniques available. Microfluidic technology provides promising features for high-performance manipulation and sorting applications as it allows precise and accurate control of the driving forces. Among the different driving force fields that could be applied, ultrasound-driven acoustic forces have often been used since they allow for gentle, label-free and purely mechanical manipulation of particle and cell suspensions. We use front-edge experimental velocimetry and particle tracking techniques combined with numerical simulation tools to investigate and improve acoustofluidic micro-systems, with applications for particle manipulation and sorting (high-throughput, higher viscosity, different particle deformability and shape).


Partners: DTU Denmark (Prof. Bruus), Lund University (Prof. Laurell)


Contacts: Dr. Alvaro Marin, Dr. Massimiliano Rossi